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Identification and characterization of sperm-specific components required for female meiosis in C. elegans
DownloadSpring 2022
In most sexually reproducing animals, sperm entry provides the signal to initiate the final stages of female meiosis. The molecular mechanism of this process is still unclear. In C. elegans, three maternally-expressed paralogs, memi-1, 2 and 3 (meiosis-to-mitosis) are required for sensing sperm...
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Spring 2015
Spindle assembly pathways are conserved in many organisms. Defects in spindle assembly can result in aneuploidy, a common cause of cell death and cancer. A better understanding of spindle assembly pathways is required to fully appreciate how defects in spindle assembly manifest as aneuploidy and...