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Spring 2020

Krys, Daniel

Positron Emission Tomography (PET) utilizes radioactively tagged molecules to identify cancerous tissue. In most cases, membrane transporters control entry of these molecules into human cancer cells. Hypoxia-inducible factor (HIF)-1 is the master homeostatic regulator during hypoxia in human...

Spring 2016

Roggenbeck, Barbara A

Arsenic is a proven human carcinogen and associated with a myriad of other adverse health effects. This metalloid is methylated in human liver to monomethylarsonic acid (MMAV), monomethylarsonous acid (MMAIII), dimethylarsinic acid (DMAV), and dimethylarsinous acid (DMAIII) and eliminated...

Fall 2020

Kaur, Gurnit

Over 200 million people worldwide are exposed to the proven human carcinogen arsenic, due to contaminated drinking water. Animal studies have shown that arsenic and the essential trace element selenium can undergo mutual detoxification through the formation of the seleno-bis(S-glutathionyl)...

Fall 2022

Zhou, Janet R

Chronic exposure to arsenic causes lung, skin, and bladder cancer in humans. Conservative estimates suggest at least 92-220 million people worldwide are exposed to arsenic through consumption of contaminated water. Unfortunately, removal of arsenic from contaminated water sources is not...

Spring 2014

Carew, Michael W

Arsenic is a potent environmental contaminant and human carcinogen, occurring naturally in the earth’s crust and entering the food chain through leeching into the water supply. Upon entering the body, inorganic arsenic is methylated to mono- and di-methylated forms, the trivalent versions of...