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Skip to Search Results- 1Benson, Curtis A
- 1Catuneanu, Ana
- 1Chambers, Daniel B
- 1Friedman, Timothy N.
- 1La Caprara, Olivia R
- 1Olechowski, Camille J
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Exploring Novel Therapies for Motor and Non-Motor Symptoms in a Mouse Model of Multiple Sclerosis
DownloadSpring 2016
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterized by neurodegeneration, inflammation and demyelination. Symptoms of multiple sclerosis not only include motor deficits, but also secondary symptoms of pain, depression and anxiety. The purpose of...
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Fall 2023
The overarching idea of this thesis stemmed from previous work in our lab, where it was noticed that females and males exhibited different disease trajectories in a model of Multiple Sclerosis. Combined with our observation of different outcome metrics for peripheral nociception suggested that...
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Peripheral contribution to pain hypersensitivity in a T-cell mediated model of multiple sclerosis: The female perspective
DownloadSpring 2020
Multiple sclerosis (MS) is a neuroinflammatory disease characterised by immune activation, demyelination, and degeneration in the central nervous system (CNS). Chronic pain is a common symptom of MS and current treatment options for pain in MS are ineffective. Pain arises from aberrant...
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Sex Differences in Central Nervous System Plasticity and Pain in Experimental Autoimmune Encephalomyelitis
DownloadSpring 2019
Multiple sclerosis (MS) is a neurodegenerative autoimmune disease with many known structural and functional changes in the central nervous system (CNS). A well-recognized, but poorly understood, complication of MS is chronic pain. Little is known regarding the influence of sex on the development...
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The glutamate transporters' role in neuropathic pain and cognitive deficits in an animal model of multiple sclerosis
DownloadFall 2013
Multiple Sclerosis (MS) is a chronic disease of the central nervous system characterized by demyelination, inflammation and axonal injury. Chronic pain and cognitive deficits affect a large percentage of MS patients. While a number of animal models are available to study the pathophysiology of...
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Fall 2023
The immune system interacts reciprocally with the nervous system in order to accomplish facets of innate immunity via various mechanisms including toll-like receptors (TLRs). TLR activity leads to the release of cytokines which can effect acute and chronic pain states by promoting afferent neuron...
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Fall 2014
Fragile X Syndrome (FXS) is the most common genetic cause of Intellectual Disability, affecting 1 in 4000 boys and 1 in 6000 girls. Work in our lab using Drosophila melanogaster and since replicated in the mouse model has shown that excess protein synthesis is a major mechanism connecting the...