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Skip to Search Results- 2Clavam
- 12, 4 diamino butyric acid
- 1Clavulanic acid
- 1Gene clusters
- 1Non-ribosomal peptide synthetase
- 1Paralogous genes
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Characterization of the gene cluster encoding a non-ribosomal peptide synthetase for polymyxin biosynthesis in Paenibacillus polymyxa PKB1
DownloadSpring 2011
Polymyxins are cationic lipopeptide antibiotics, and are considered to be drugs of last resort to fight against multidrug resistant Gram negative bacteria. In this study the gene cluster encoding the non-ribosomal peptide synthetase which catalyses polymyxin biosynthesis was identified and...
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Spring 2011
Production of clavams (including clavulanic acid, a potent β-lactamase inhibitor) has been studied in Streptomyces clavuligerus. All clavams share the early biosynthetic steps. However, many of the late steps of the pathway remain unclear. Streptomyces antibioticus Tü1718 was chosen for this...
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Spring 2011
Streptomyces clavuligerus is capable of producing various secondary metabolites including clavulanic acid. The biosynthetic pathway of clavulanic acid is partially shared with other structurally related 5S clavams. The first reaction involved in clavam biosynthesis is catalyzed by...