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Skip to Search Results- 1High Molecular Weight Proteins
- 1Isotope Labeling
- 1Selective Methyl Group Protonation
- 1Side Chain Dynamics
- 1Solution NMR
- 1cardiac troponin
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Spring 2021
Heart muscle contraction is regulated by calcium binding to cardiac troponin C. This induces troponin I (cTnI) switch region binding to the regulatory domain of troponin C (cNTnC). Compounds that directly modulate the interface of cNTnC and cTnI switch region have potential for treating heart...
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Novel Isotope Labeling Strategies for NMR-Based Structure Determination of High Molecular Weight Proteins
DownloadSpring 2023
Solution NMR studies of high molecular weight proteins suffer from inadequate side-chain information and rapid signal decay. Selective 1H, 13CH3-methyl labelling of perdeuterated proteins has been the standard approach addressing these limitations but suffers from a lack of information about the...