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Effect of environmental exposure on infant gut microbiota composition and diversity in the Canadian Healthy Infant Longitudinal Development (CHILD) national birth cohort
DownloadFall 2016
Background: The development of infant gut microbiota plays a crucial role in immune system development, and infant gut microbiota dysbiosis has been linked to asthma and allergic disease. Studies have shown that Bacteroidetes phylum was less abundant in the guts of allergic children. Although...
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Exploring the Association of Maternal Covid-19 Infection and Epigenetic Regulation of Metabolic Pathways in Newborn Children
DownloadFall 2024
Abstract Background: SARS-CoV-2 infection during pregnancy has emerged as a significant concern due to its potential implications for fetal health. Viral infections can induce inflammatory responses and immune activation in pregnant individuals, which may harm the developing fetus through...
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Spring 2017
Introduction: Genome wide association studies (GWAS) have been widely used in recent years to identify the new information on genetic variants which are associated with complex trait in many diseases. Advances in identifying the Single nucleotide polymorphisms (SNPs) facilitate the study of...
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Updating Local Birth Weight Percentiles and Statistical Methods Motivated by Challenges in Analysis of Microbiome Studies
DownloadFall 2022
This dissertation contains two main parts. In part one, I updated the current reference for sex-specific birth weight percentiles by gestational age, overall, and for specific ethnic groups, based on data from all singleton live-birth deliveries from 2005 to 2014 in Alberta, Canada. Crude and...