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Skip to Search Results- 3Phage display
- 1Blood group glycans
- 1Deep-sequencing
- 1Fragment-based discovery
- 1Glycan Array
- 1Glycopeptide
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Spring 2016
Carbohydrates play vital roles in many disease pathologies, including inflammatory disease, cancer metastasis, autoimmune disease and pathogenic infection. Despite their significance and immense opportunity for pharmaceutical application, carbohydrate-derived drugs only constitute a relatively...
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In vitro compartmentalization and deep sequencing enable discovery of functional cell-binding ligands by phage display
DownloadFall 2015
Phage display is a technique that accelerated the discovery of peptide and protein-based ligands to numerous targets in academia and industry. Many FDA-approved antibodies and peptides on the market have originated from phage display experiments. However, one of the main drawbacks to this...
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Fall 2021
Human serum has a diverse pool of anti-glycan antibodies generated as an immune response to glycans presented by pathogens, tumor cells and vaccines. Low concentrations of antigens are often difficult to detect which renders anti-glycan antibodies as potential biomarkers for disease diagnosis and...
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Phage Display as a Combinatorial Chemistry Platform for Discovery of Chemical Structure-Activity Relationships
DownloadFall 2018
Optimization of chemical reactions, discovery of optimal substrates and determination of substrate scope involve exhaustive screening of conditions as well as measurements of rates and conversions for all series of structurally similar substrates. These systematic screenings used in reaction...