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- 1Bicyclic Peptides
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- 1Genetically encoded
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Spring 2022
Phage display libraries bearing natural amino acids are commonly used for discovering potential therapeutic macrocycles; however, direct application of those linear peptides often leads to poor pharmacokinetics, including low serum stability, lower cell membrane permeability, and rapid renal...
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Light Responsive Linchpins for Accelerated Discovery of Light-Responsive Mono- and Bicyclic Peptide Ligands
DownloadSpring 2016
In this thesis I describe the development and application of light-responsive (LR) linchpins for efficient discovery of LR-peptides from genetically encoded peptide librar-ies. LR-linchpins have been used for dynamic control of the structure of peptides and their biochemical properties such as...