This decommissioned ERA site remains active temporarily to support our final migration steps to https://ualberta.scholaris.ca, ERA's new home. All new collections and items, including Spring 2025 theses, are at that site. For assistance, please contact erahelp@ualberta.ca.
Search
Skip to Search Results-
Blood-brain barrier permeability following intracerebral hemorrhage is related to local ion dyshomeostasis
DownloadFall 2017
Background: Increased blood-brain barrier (BBB) permeability is seen after intracerebral hemorrhage (ICH). Following ICH, BBB dysfunction occurs due to direct (e.g. mechanical damage) and indirect (e.g. inflammation) injury. Damage to the BBB prevents maintenance of brain homeostasis. This thesis...
-
Fall 2020
Intracerebral hemorrhage (ICH), when a blood vessel ruptures within the brain, affects approximately 15% of stroke victims in Canada. There are no proven neuroprotective treatments ICH but two therapies, therapeutic hypothermia (TH) and iron-chelators, have gained preclinical and clinical...
-
Raised intracranial pressure and tissue compliance after large intracerebral hemorrhages in animal models and patients
DownloadFall 2022
Brain injuries that cause mass effect, including stroke and traumatic brain injury, can increase intracranial pressure (ICP) due to the limited space within the skull. Intracerebral hemorrhage (ICH) is a subtype of stroke in which there is bleeding in the brain. In cases of large bleeds, the...
-
Spring 2021
Therapeutic hypothermia (TH) is a common intervention used in a variety of injury profiles. However, when applied to intracerebral hemorrhage (ICH), TH can worsen outcome. Previous research from our lab has shown that TH can aggravate intracranial bleeding both during cooling induction and...
-
Spring 2016
Mild therapeutic hypothermia (HYPO), decreasing brain temperature to 32-35°C, is the gold standard neuroprotectant against ischemia. Cooling also ameliorates several cell death mechanisms in other types of brain injury (e.g., traumatic brain injury). As with many other neuroprotectants, HYPO not...