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Fall 2021
Rationale: The Dlx1/Dlx2 double knockout (DKO) mouse demonstrates major defects during retina development including significantly reduced number of retinal ganglion cells (RGCs) due to enhanced apoptosis of RGCs and consequently thinning of the optic nerve. In addition, the Dlx1/Dlx2 DKO mouse...
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Fall 2022
Endochondral ossification is a skeletal development process where mesenchymal progenitors differentiate into chondrocytes that will be eventually replaced by bone. Disrupting this process causes skeletal dysplasia. FOXC1 and FOXC2 are two transcription factors of the forkhead box family that...