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Colorectal Cancer Small Extracellular Vesicles Induce Matrix Metalloproteinase Expression, an Invasion-Promoting Phenotype, and CD147-Dependent MAPK/AP-1 Activation in Macrophages
DownloadFall 2020
Exosomes and small microvesicles are types of small extracellular vesicle (sEVs) secreted by cancerous and normal cells. sEVs are filled with cargo from cancer cells that may affect both nearby and distant tissues. sEVs from colorectal cancers that enter blood vessels draining the intestine will...
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Regulation of Anti-tumor Immunity in Colorectal Cancer by Interaction of Exosome Immune Complexes with Fc gamma Receptors
DownloadSpring 2019
Targeted therapy is difficult for colorectal cancer (CRC) due to lack of conserved tumor associated antigens (TAA). Immunotherapies for CRC directed at TAA that can overcome intestinal tolerance need to be developed to improve survival of CRC patients. Exosomes are extracellular vesicles secreted...