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Skip to Search Results- 1 Lansing, Marihan
- 1Abu Alrub, Osama Y
- 1Ahrari, Malema
- 1Ali, Amber Z
- 1Ali, Noureen
- 1Allan, Chantal J
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Membrane Type 1-Matrix Metalloproteinase Mediates Degradation of the Low-density Lipoprotein Receptor Family Members
DownloadSpring 2024
The low-density lipoprotein receptor (LDLR) family includes 13 transmembrane protein members sharing a conserved structure and common repeats. Their importance has been shown in a variety of physiological and pathophysiological events including lipid metabolism, nervous system development and...
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Spring 2020
Stress induced by pain and anxiety is common in pediatric intensive care unit (PICU) patients and can impede the delivery of critical care to children as well as their recovery. Sedation and analgesia in PICU is usually achieved through the use of various analgesics and sedatives, often narcotics...
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Fall 2023
Heart failure is a condition whereby the weakened cardiac muscle can no longer pump blood to the rest of the body, resulting in decreased quality of life. Despite the severity of this debilitating condition, there is no cure for heart failure. Modulation of cardiac energy metabolism has become an...
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Spring 2012
The surgical repair of congenital heart defects (CHDs) often requires a bloodless/motionless field achieved by arresting the neonatal heart and exposing it to a period of ischemia. Metabolic manipulation, such as suppression of fatty acid (FA) oxidation, improves post-ischemic functional recovery...
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Spring 2016
Cerebral Palsy (CP) constitutes the primary outcome of premature nerve injury. Impairment of oxygen and glucose supply during pregnancy to the fetus can induce neuron damage and death. Mental retardation, seizures, learning disabilities, and other mental diseases can occur as a result of this...
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Nonmedical Use of Opioids Following Short Term Therapeutic Exposure in Children and Youth: A Systematic Review and Qualitative Study of Decision Maker Information Needs
DownloadFall 2021
Introduction Healthcare visits, hospitalizations, and deaths due to opioid-related harms continue to rise for children, despite an overall decline in opioid prescriptions. Decision-makers (including patients, families, clinicians, and policy-makers) require high quality syntheses to inform...
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Fall 2022
Glioblastoma has a devastating prognosis, and a remarkably low survival rate. Current therapeutic strategies including surgery, radiation and temozolomide are only useful as a palliative therapy, with no significant increase in overall survival. In this study, we investigated multiple therapeutic...
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Fall 2014
Inflammatory bowel disease (IBD) is chronic relapsing and remitting inflammation of the gastrointestinal tract resulting in abdominal pain, diarrhoea and weight loss. The two major types of IBD are Crohn’s disease (CD) and ulcerative colitis (UC). Genetic analysis has implicated several genomic...
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Novel Treatments for Intestinal Failure Explored in Neonatal Piglets with Short Bowel Syndrome: Focusing on the Microbiome, Sepsis and Trophic Factors
DownloadSpring 2024
Short bowel syndrome (SBS) is the leading cause of intestinal failure (IF) in infants, and occurs when there is a significant loss of intestine due to acquired or congenital reasons, leading to infants being unable to absorb sufficient nutrients for survival and growth. SBS traditionally had a...
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Osteosarcoma (OS) progression is associated with increased nuclear levels and transcriptional activity of Active-β-catenin (ABC)
DownloadSpring 2019
Osteosarcoma (OS) is an aggressive primary bone malignancy having peak incidence in children and young adults <25 years of age. Outcome remains poor for most patients with metastatic disease which develops in 1 of every 5 cases. However, despite the use of multimodal chemotherapeutic and surgical...