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Skip to Search Results- 1Adesunkanmi, Maryam
- 1Aljunaidy, Mais
- 1Barghout, Samir H
- 1Coatham, Mackenzie L.
- 1Demsky, Ashley N
- 1Fakhr, Yuliya
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Spring 2023
The human placental surface is lined by a giant multinucleate epithelial cell – the syncytiotrophoblast (ST). The ST acts a maternal-fetal interface and aids in the exchange of gas, nutrient exchange, and acts as a transient endocrine organ. This ST layer is formed and maintained by the...
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Cesarean Section and other Birth Interventions: impact on Clostridioides difficile (C. difficile) colonization in the infant gut microbiota in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort
DownloadSpring 2019
Abstract Background Medical interventions during childbirth are increasing, with cesarean section (CS) delivery exceeding recommended rates by 13-15 % in Canada. CS has been associated with gut dysbiosis in early life. Infants who bypass this beneficial maternal bacterial inoculation during...
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Spring 2022
Some of the most aggressive endometrial cancer cases display extensive heterogeneity within the same tumor in the form of mixed undifferentiated and well-differentiated phenotypes. The emergence of dedifferentiation in higher grade endometrial carcinomas presents an obstacle for both timely and...
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Epidemiology of Neurodevelopmental Disorders among Indigenous Children: from Global to Métis-specific Contexts
DownloadFall 2022
Neurodevelopmental disorders (NDDs) have been found to be more prevalent among Indigenous children. However, it is unclear whether this extends to all Indigenous children from countries with similar colonial histories. In this thesis, we conducted a systematic review to assess the evidence on the...
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Indigenous Mental Health During the COVID-19 Pandemic: A Scoping Review of the Literature and Gendered Analysis of Métis Experiences
DownloadFall 2023
The COVID-19 pandemic impacted the mental health of the global population. Indigenous Peoples have been disproportionately affected by previous pandemics and already face an increased vulnerability to poor mental health outcomes due to the damaging and enduring effects of colonialism. However,...
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Spring 2016
Preeclampsia, defined as new-onset hypertension after 20 weeks of gestation with concurrent proteinuria, is the leading cause of maternal mortality. Preeclampsia is a multi-system disorder with serious maternal and fetal morbidities, which affects 2 – 8% of pregnancies worldwide. Although the...
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Mechanosensory and Sphingolipid Mediators of Inflammatory Signaling in Placental Dysfunction
DownloadFall 2022
Preeclampsia (PE) is a leading cause of maternal and fetal morbidity. Placental dysfunction plays a key role in PE and includes decreased syncytialization and increased inflammation and cell death. Tumor Necrosis Factor alpha (TNF-α) is a key factor in inducing this dysfunction. The controversy...
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Novel mechanisms of carboplatin resistance in epithelial ovarian cancer and their therapeutic potential
DownloadFall 2015
Ovarian cancer is the fifth leading cause of cancer-related mortality in women. Epithelial ovarian cancer (EOC) constitutes approximately 90% of all ovarian malignancies. Platinum-based compounds have been used to treat EOC, with carboplatin currently being used as a first-line therapeutic agent...
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Obstetrician and Gynecologist’s Perspectives on the Definition and Management of Obesity in Pregnancy
DownloadFall 2019
Introduction: Obesity is a complex disease affecting increasing numbers of reproductive aged women. Despite ongoing research efforts, many knowledge gaps remain when caring for women with obesity in pregnancy. Currently, there is no clearly defined, comprehensive standard of care for pregnant...
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Prenatal Hypoxia and the Impact of Maternal Antioxidant (MitoQ) Treatment on Developmental Programming of Cardiovascular Disease
DownloadFall 2018
Cardiovascular disease is the primary cause of morbidity and mortality worldwide. Prenatal hypoxia (due to placental or maternal hypoxia) is an established risk factor for cardiovascular disease. Hypoxia in pregnancy can lead to intrauterine growth restriction (IUGR; defined as a fetus who does...