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Spring 2019

Alshememry, Abdullah

Hypoxic-ischemic brain damage (HIBD) is a major concern during the neonatal period, and can result in chronic neurological complications arising from damage to the term newborn brain. Delivering drugs at the site of brain injury is thought to be crucial to the advancement of therapy for these...

1993

Agudoawu, Sammy Asiamah.

Fall 2013

Turkistani, Abdullah A

FoxO transcription factors are downstream mediators of insulin effects that can bind to DNA and regulate transcription of multiple target genes. These target genes are known for their importance in several biological functions including energy homeostasis, longevity, tumour suppression...

2006

Harirforoosh, Saeidreza

Fall 2023

Yukuyama, Megumi N

Nanoemulsions have wide application, presenting several properties such as the solubilization of poorly soluble drugs in water, promoting the increase of their bioavailability, allowing greater stability of the formulation and, due to its property as a carrier, promoting their modified release....

2002

Pickard, Alan Simon

Spring 2013

Alsaad,Abdulaziz M

Drug-induced cardiotoxicity is classified as a predisposing factor leading to cardiac hypertrophy and heart failure. Of importance, doxorubicin (DOX, adriamycin) is considered as an effective anticancer agent whose major limiting side effect is cardiotoxicity. Of importance, several studies...

Fall 2011

Abukhashim, Mohamed

Cytochrome P450 epoxygenases metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs), which in turn are converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH). EETs are known to modulate a number of vascular and renal functions but the exact signaling...

Spring 2016

El-Sikhry, Haitham E

Mitochondria are at the center of cardiac health and disease. These vital organelles provide most of the energy to the contractile apparatus and play a strategic role in cardiomyocyte survival during cellular stress. Cardiovascular diseases and many aging related diseases are often associated...

Spring 2018

Tang, Kathy Cheng-Chia

Forkhead Box O transcription factors play important roles in bone metabolism via defending against oxidative stress and apoptosis (Almeida, 2011; Ambrogini et al., 2010). FoxO3a is of special interest as it is the predominant isoform in bone cells (Ambrogini et al., 2010). In osteoblasts, the...