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Skip to Search Results- 366Faculty of Pharmacy and Pharmaceutical Sciences
- 4Faculty of Medicine
- 2Faculty of Medicine and Oral Health Sciences
- 1Department of Biomedical Engineering
- 1Department of Medical Sciences
- 1Department of Medicine
- 1AL Omair, Omar Abdulrahman
- 1AL-AGILI, MARWA
- 1Abdelmoneim, AS
- 1Abdulsalam Alharbi
- 1Abdussalam, Ali MA
- 1Abed,Hadeel
- 15Pharmacokinetics
- 8Cytochrome P450
- 6Cancer
- 6Monoclonal antibodies
- 6Polymeric micelles
- 5Arachidonic acid
- 8El-Kadi, Ayman (Faculty of Pharmacy and Pharmaceutical Sciences)
- 6El-Kadi, Ayman (Pharmacy and Pharmaceutical Sciences)
- 6Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
- 5Brocks, Dion (Pharmacy and Pharmaceutical Sciences)
- 5Yuksel, Nese (Faculty of Pharmacy and Pharmaceutical Sciences)
- 4Doschak, Michael (Pharmacy and Pharmaceutical Sciences)
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Mobile technology interventions for improving medication adherence in patients with mental health disorders
DownloadFall 2017
ABSTRACT Poor medication adherence in the mental health population leads to compromised treatment outcomes and increased health care costs. Traditional interventions for medication adherence, while effective if addressing multiple determinants of medication-taking behavior, are expensive and...
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MODULATING CYTOCHROME P450-MEDIATED ARACHIDONIC ACID METABOLISM AS A POTENTIAL NEW TREATMENT MODALITY FOR CARDIAC HYPERTROPHY
DownloadSpring 2017
El-Sherbeni, Ahmed Abd El-Hakeem
Arachidonic acid (AA) metabolism has long been a very appealing target for drug discovery and development efforts. Beside cyclooxygenase and lipoxygenase pathways, AA is also metabolized by the recently recognized cytochrome P450 (P450) pathway, forming several biologically-active...
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MODULATION OF ARYL HYDROCARBON RECEPTOR (AHR)-REGULATED CARCINOGEN ACTIVATING ENZYMES BY ORGANIC ARSENICALS: A POTENTIAL THERAPEUTIC TARGET
DownloadSpring 2017
Arsenic is a worldwide environmental pollutant that is associated with skin and several types of internal cancers, such as liver, lung, kidney, urinary bladder, and prostate cancers. Recent reports revealed that organic arsenic metabolites, such as trimethylarsine oxide (TMAO), dimethylarsinic...
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MODULATION OF ARYL HYDROCARBON RECEPTOR (AHR)-REGULATED XENOBIOTIC METABOLIZING ENZYMES BY ARSENITE
DownloadFall 2013
Anwar-Mohamed, Anwar Gamal Abd El-Naser
Aryl hydrocarbon receptor (AhR) ligands and heavy metals are environmental co-contaminants and their molecular interaction may disrupt the coordinated regulation of AhR-dependent phase I and II drug metabolizing enzymes. As such, the effect of the heavy metal, As(III), on the AhR-regulated genes...
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Fall 2013
Aryl hydrocarbon receptor (AhR) ligands such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and metals, such as mercury (Hg), are environmental co-contaminants with multiple biological consequences. Therefore, the objectives of the current dissertation were to: 1) examine the potential effect of...
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Myeloperoxidase-mediated bio-activation of NSAIDs in leukemia cells: Potential selective cytotoxicity
DownloadFall 2019
Several lines of evidence have pointed to the potential benefit of anti-inflammatory drugs (NSAIDs) in cancer therapy due to the well-established correlation between cancer and chronic inflammation. Acute myeloid leukemia (AML) cells overexpress myeloperoxidase (MPO), which has been studied for...
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Spring 2023
As the most metabolically demanding organ in the body, the heart must continually produce extraordinary amounts of energy to sustain constant contractile function. To accommodate for alterations in fuel source availability, the healthy mature heart is omnivorous and possesses the capacity to...
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Fall 2016
Macrophages are the primary cells of innate immunity that provide the first line of defence against any external stimuli. Their phagocytic properties enable them to engulf invading microbes or foreign particles. The phagocytic capability of macrophages plays a major role in interfering with drug...