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Skip to Search Results- 1Al-Hallak, MHD Kamal
- 1Alarifi, Saqer
- 1Almukainzi, May
- 1Almukainzi, May Khalifah
- 1Alshikhey,Areej
- 1Amaral Silva, Daniela
- 4Dissolution
- 2Bicarbonate buffer
- 2Lung cancer
- 2Microemulsion
- 1Anti-apoptotic proteins
- 1BCS Classification
Results for "Raimar"
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Veterinary compounding: In vitro assessment of Methimazole-based foam for feline hyperthyroidism
DownloadFall 2018
Veterinary compounding: In vitro assessment of Methimazole-based foam for feline hyperthyroidism Areej Alshikhey, Raimar Löbenberg, Michael Doschak Objective: Hyperthyroidism is one of the most common feline endocrine disorders due to excess production of active thyroid hormone in middle-aged cats
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Gelled and Foamed Microemulsion-based Systems for Cutaneous Drug Delivery of Diclofenac Sodium
DownloadFall 2017
Abstract Topical formulations of diclofenac have become popular for treating various painful inflammatory conditions. Yet, not all formulations are suitable candidates for dermal delivery as the skin acts as a natural barrier that limits drug penetration. This barrier challenges the efficacy of...
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The application of computer simulation to investigate drug absorption and bioavailability in disease states
DownloadFall 2015
Oral drug absorption relies mainly on the physicochemical drug properties and the interaction with the physiological environment of the body. These factors could be altered significantly under abnormal conditions and disease states. Identifying these changes can optimize drug therapy under these...
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Evaluation of performance testing and computer simulations for Quality by Design approaches of oral dosage forms
DownloadSpring 2011
Performance testing and computer simulations have promising applications in Quality by Design approaches. The objectives of these studies were to investigate the performance of the disintegration test using different setups in addition to comparing the performance of the disintegration test with...
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Mechanistic Dissolution Modeling of a Poorly Soluble Drug; an Evaluation of Formulation Influence and Simulation Parameters for Enhancing Predictive Capability
DownloadFall 2019
In early drug development, the selection of a formulation platform and decisions on formulation strategies have to be made within a short timeframe and often with minimal use of the active pharmaceutical ingredient (API). At this stage, there is limited information available about the...
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The Dissolution Behavior of Ibuprofen and Griseofulvin in Bicarbonate Buffer Compared to Phosphate Buffer Using Intrinsic Dissolution Rate and Biphasic Dissolution
DownloadFall 2018
In the small intestine, bicarbonate is the main buffering system to adjust the pH after the gastric emptying to pH 5.5-6.8. Bicarbonate gathered some attention to be used as a dissolution media to better mimic the in-vivo environment. However, in vitro the evaporation of CO2(g) interferes with...
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Inhalable nanoparticles in lung cancer treatment; efficacy, safety, distribution and nanoparticle-macrophage interactions
DownloadFall 2012
In 2002, lung cancer was responsible for 17.6% of the total worldwide deaths from cancer. Beyond the three traditional forms of cancer treatment, surgery, radiation therapy, and chemotherapy, targeted drug delivery therapy has shown to be a potential treatment option. The design of a successful...
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Erding formula and bioactive markers in hyperuricemia: towards rational scientific approaches for the modernization of Traditional Chinese Medicine
DownloadSpring 2019
Introduction: Traditional Chinese Medicine (TCM) represents one of the first holistic approaches in the world to treat and prevent disease. Herbal medicine is one of the major therapeutic remedy in TCM. It often involves multi-herb therapies instead of single herb preparations. Parallel to...
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Fall 2013
Gluten-sensitive enteropathy, called Celiac disease (CD), is one of the most frequent autoimmune diseases, occurring in 1% people worldwide, upon gliadin ingestion. Currently, the only treatment available for CD individual is a strict life-long gluten-free diet. Chicken egg yolk immunoglobulin Y...
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Buparvaquone Nanostructured Lipid Carrier Development: Physicochemical and In Vitro Leishmanicidal Performances
DownloadSpring 2018
Leishmaniases is a group of diseases caused by parasites of the genus Leishmania. The estimated number of deaths from visceral leishmaniases ranges from 20,000 to 50,000 annually. The most common treatment over the past 60 years has been pentavalent antimonials. Besides the doubtful...