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Skip to Search Results- 6Bigam, David (Surgery)
- 1Cheung, Po-Yin (Pediatrics, Pharmacology and Surgery)
- 1Cheung, Po-Yin (Pediatrics, Pharmacology)
- 1Cheung, Po-Yin (Pharmacology/Surgery/Pediatrics)
- 1Freed, Darren (Surgery, Physiology, Biomedical Engineering)
- 1Shapiro, A.M. James (Surgery)
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Fall 2010
With asphyxia, newborns may suffer cardiogenic shock with myocardial dysfunction and dysregulation of vasomotor tone resulting in multiorgan dysfunction. Vasoactive medications are often administered with limited evidence directing clinicians regarding the use of high-dose monotherapy with...
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Fall 2023
Normothermic machine perfusion (NMP) is a novel method of organ preservation that has recently risen in prominence. NMP involves the maintenance of an organ outside the body to recreate its physiologic milieu, such as by providing oxygen and nutrients and maintaining temperature. We are only just...
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Fall 2019
Waitlist mortality resulting from a shortage of transplantable liver grafts has led to increased use of donation after circulatory death (DCD) grafts. However these marginal grafts are associated with higher complication rates. Normothermic ex-situ perfusion of DCD livers has shown encouraging...
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Fall 2013
Asphyxia is a significant cause of newborn morbidity and mortality. Multiorgan injury and dysfunction is a common finding, mediated in part through an increase in matrix metalloproteinase (MMP) activity. We hypothesized administration of doxycycline, a known MMP inhibitor, would improve systemic...
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Trophic peptide therapies for neonatal short bowel syndrome: actions and mechanisms studied in a preclinical model
DownloadFall 2016
Short bowel syndrome (SBS) occurs when a significant length of intestine is surgically resected for both congenital and acquired intestinal abnormalities and remains a significant cause of morbidity and mortality in neonates. With an insufficient amount of intestine available for nutrient...
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Fall 2013
Cardiovascular dysfunction in asphyxiated neonates leads to significant morbidity and mortality and the hemodynamic support is limited to the use of catecholamines. In a pilot study, we showed that low-dose vasopressin improved myocardial tissue lactate levels, suggesting decreased anaerobic...