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Skip to Search Results- 1Adaptive Immunity
- 1Adenovector
- 1Caulobacter crescentus
- 1Coinhibition
- 1Costimulation
- 1Dendritic cells
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Activation of Natural Killer T cells and Dendritic cells with Caulobacter crescentus: Implications for developing tumour immunity
DownloadSpring 2013
Cancer remains a leading cause of mortality worldwide. Efforts to develop immuno-therapies to control the growth of cancer, while limiting host cell damage, have focused on targeting specific tumour associated antigens. These treatments have yielded some clinical success however; the limited...
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Fall 2015
Hepatitis C virus (HCV) leads to chronic infection in the majority of infected patients presumably due to failure or inefficiency of the immune responses generated. Both antibody and cellular immune responses have been suggested to be important in viral clearance. Non-replicative adenoviral...
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Fall 2009
MUC1, a protein of epithelial and carcinoma cells, has recently been shown on activated T cells where it inhibits CD3-stimulated proliferation. Two immunoregulatory domains similar to ITAM and ITIMs are present on its cytoplasmic tail, suggesting that MUC1 can act as both a costimulatory and...