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Skip to Search Results- 1AE3
- 1Bicarbonate transport
- 1Bicarbonate transporters, carbonic anhydrase
- 1Carbonic anhydrase
- 1Chloride/bicarbonate exchanger AE1
- 1Heart failure
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Spring 2012
Cardiac hypertrophy is maladaptive remodeling of the myocardium that often progresses to heart failure. The hypertrophic transport metabolon consists of membrane transporters implicated in hypertrophy, and substrates for these transporters are provided by the catalytic action of carbonic...
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Spring 2014
NHE1, whose activity and expression are elevated in cardiac hypertrophy, requires an acidifying pathway provided by AE3-mediated Cl-/HCO3- exchange to sustain its activity. Carbonic anhydrase II (CAII) interacts with NHE1 and AE3 to induce hypertrophy but the role of AE3 in hypertrophy is poorly...