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Skip to Search Results- 2Muller, Milan J.
- 1Abeywardena, Mahinda Yapa
- 1Abou-Chehade, Kassim D.
- 1Adjei, Alex Asiedu.
- 1Al-Majed, Abdulhakeem A
- 1Ali, Mohammad M. A.
- 5Rats as laboratory animals.
- 4GABA. Receptors.
- 4Metalloproteinases. Physiological effect.
- 4Pharmacology
- 3Adenosine
- 3Autophagy
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Exploring the Regulation of Kv1.2 Homomeric and Heteromeric Channels by Redox, LMAN2, and Kvβ
DownloadFall 2023
Voltage-gated potassium channels generate diverse current properties influenced by various signaling mechanisms that are still not well understood. Among these channels, Kv1.2 in particular demonstrates highly variable activation properties based on their ability to shift between a fast...
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Function and Regulation of Equilibrative Nucleobase Transporter 1 in Acute Lymphoblastic Leukemia
DownloadFall 2024
Background: 6-Mercaptopurine (6-MP) is a purine nucleobase analog used for the treatment of acute lymphoblastic leukemia (ALL), inflammatory bowel disease, and other disorders. 6-MP is primarily used in ALL, the most common childhood cancer. Enzymes involved in 6-MP metabolism have been shown to...
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Spring 2024
6-Mercaptopurine (6-MP) maintenance therapy is the mainstay for various types of leukemia and inflammatory bowel disease (IBD). 6-MP is associated with numerous adverse effects including gastrointestinal intolerance, myelotoxicity and hepatotoxicity. This can lead to therapy discontinuation which...
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GABAA Receptors and Tonic Inhibition: Towards an Improved Understanding of Agonist Binding and in vivo Expression of the Extrasynaptic a4b3d Subtype
DownloadFall 2013
The GABAA receptor is the major inhibitory neurotransmitter receptor in the central nervous system. Receptors containing the delta subunit generate tonic inhibition due to their extrasynaptic expression, high affinity for gamma-aminobutyric acid (GABA), and slow densensitization kinetics. The...
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Spring 2016
Heart failure is associated with major changes in cardiac energy metabolism that decrease cardiac efficiency, which can reduce cardiac function. In severe heart failure there is a shift back toward a fetal heart metabolism, with a decrease in mitochondrial oxidative metabolism and increase in...