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Fall 2018
Epilepsy is among the most common neurological diseases, but approximately 30% of epileptics are unresponsive to available drugs, and many more suffer significant side effects. One reason for the persisting large fraction of drug-resistant or drug-intolerant patients may be that most drug...
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Exploring the Regulation of Kv1.2 Homomeric and Heteromeric Channels by Redox, LMAN2, and Kvβ
DownloadFall 2023
Voltage-gated potassium channels generate diverse current properties influenced by various signaling mechanisms that are still not well understood. Among these channels, Kv1.2 in particular demonstrates highly variable activation properties based on their ability to shift between a fast...
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Spring 2021
Slow gating regulation is an extrinsic regulatory mechanism that inhibits the activation of Kv1.2 channels. Physiological factors modulating slow gating regulation are incompletely understood and the interplay between slow gating regulation and Kv1.2 channel pharmacology is unexplored. In chapter...
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Pharmacological and Fluorometric Assessment of Neuronal KCNQ Channels, and Implications for Understanding Neurological Disease
DownloadSpring 2020
Epilepsy affects 60 million people worldwide, and encompasses the most common forms of neurological disorders. Epilepsy manifests in diverse ways in patients, ranging from mild cognitive effects, to seizures, to the more severe epileptic encephalopathy. While many pharmacological approaches exist...