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- 33Mass-spectrometry
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Structure-based design of inhibitors for the human neuraminidase enzymes NEU2, NEU3, and NEU4
DownloadSpring 2014
Sialidases (neuraminidases) are a group of enzymes responsible for the hydrolysis of sialic acid from glycoconjugates. In humans, there are four different isoenzymes that play important roles in health and disease. The human neuraminidase enzymes (hNEU) were discovered somewhat recently, and...
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Studies of a mycobacterial α-(1→4)-mannosyltransferase involved in 3-O-methyl-mannose polysaccharide biosynthesis
DownloadSpring 2013
Mycobacteria produce a number of unique carbohydrates, the majority of which are found in the cell wall of the organism. In addition to these extracellular glycans, mycobacteria also produce intracellular glycans. One class of them are the 3-O-methy-lmannose polysaccharides (MMPs), whose...
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