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Skip to Search Results- 33Mass-spectrometry
- 24Chemistry
- 23Organic compounds. Synthesis.
- 22Metabolomics
- 21Capillary electrophoresis.
- 21Catalysis
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Fall 2012
This thesis describes advanced model studies directed to the synthesis of CP- 225,917 and CP-263,114, complex natural products that have been shown to inhibit enzymes that are involved in cholesterol biosynthesis and in the development of many cancers. A route was devised to the functionalized...
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Fall 2015
This thesis describes the studies towards the total synthesis of MPC1001F, a triketomonothiopiperazine natural product. In section 2.1, the first route, based on previous studies, reached the pyrrolidinone/diketopiperazine system with correct stereochemistry but did not go to completion due to...
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Studies towards total synthesis of MPC1001F - a triketopiperazine- dihydrooxepin natural product
DownloadSpring 2013
The thesis describes synthetic studies towards MPC1001F, a triketopiperazine-dihydrooxepin natural product. Another related member of this class of natural products is MPC1001 with an epidithiodioxopiperazine core and potent antitumor activity. Our goal was to construct the molecular skeleton of...