Search
Skip to Search Results- 1Fitieh, Amira
- 1Fung, Angela Wai Shan
- 1Lazareno-Saez, Christelle
- 1Li, Zhuo
- 1Locke, Andrew J
- 1Pedrycz, Barbara J
-
Fall 2014
Fungal pathogens are recognized by Dectin-1, a pattern recognition receptor expressed on mammalian innate immune cells. Dectin-1 detects β-glucans, which are polymers of glucose that are a main component of the fungal cell wall. While purified, soluble β-glucans have been used in the clinic as...
-
Fall 2014
Multidrug resistant bacteria pose a threat to human health and economic burden for the healthcare system. Transmission of antibiotic resistance genes can occur by the conjugative transfer of the F plasmid between bacteria. The transferosome forms a channel linking the two cells together, while...
-
Insights into the Role of Choline Kinase in Endochondral Bone Formation and Human Osteoblasts Function
DownloadSpring 2014
Choline kinase (CK) phosphorylates choline to phosphocholine (PCho) and is the first enzyme in the CDP-choline pathway that generates phosphatidylcholine (PC). CK has three isoforms (CKα1, CKα2 and CKβ) that are encoded by two genes, Chkα and Chkb. Inactivation of Chkα results in embryonic...
-
Mechanistic basis of plasmid-specific DNA binding of the F plasmid regulatory protein, TraM
DownloadFall 2014
The conjugative transfer of bacterial F plasmids relies on TraM, a plasmid-encoded protein that recognizes multiple DNA sites to recruit the plasmid to the conjugative pore. In spite of the high degree of amino acid sequence conservation between TraM proteins, many of these proteins have markedly...
-
Molecular Basis of Escherichia coli L/F transferase: Catalytic Mechanism and Substrate Specificities
DownloadFall 2014
The Escherichia coli leucyl/phenylalanyl-tRNA protein transferase (L/F transferase) catalyzes the tRNA-dependent post-translational addition of amino acids onto the N-terminus of a protein polypeptide substrate. The enzymatic N-terminal addition of an amino acid to a protein has been identified...
-
Molecular Mechanisms of the Activation of the Pattern Recognition Receptor Dectin-1 and its Induction of Immune Responses
DownloadFall 2014
In the past two decades, a rising number of fungi have emerged as serious human pathogens and the incidence of invasive fungal infections has increased enormously. Millions of people contract fungal diseases that kill at least as many people as tuberculosis or malaria, yet the global burden of...
-
Fall 2014
Rhomboids are a family of intramembrane serine peptidases that cleaves a peptide bond of a substrate protein in the lipid bilayer. Various cellular processes such as cell differentiation and apoptosis have been linked to rhomboids proteolytic activty. More precisely, active and inactive rhomboids...