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Skip to Search Results- 2Lohmeier, Elke Monika, 1955-
- 2Veldhoen, Richard
- 1ALSHUMAIMERI, NADA A.
- 1Acevedo Morantes, Claudia Y
- 1Aderibigbe, Ayodeji O.
- 1Ahsan, Irfan.
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Fall 2021
Neurodegenerative diseases caused by prions afflict both humans and animals, and result from conformational conversion of the cellular prion protein, PrPC, coded for by the PRNP gene, to an isoform called PrPSc. The infectious agent of PrPSc assembles into aggregate structures and can continue...
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Molecular and cellular roles of the N-end rule pathway in apoptotic cell death in mammalian-derived cell lines
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Cellular stresses and signaling that lead to the initiation of apoptotic pathways often result in the activation of proteases such as caspases which in turn culminate in the generation of proteolytically activated protein fragments with new or altered roles. Recent work has revealed that the...
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Molecular and Epigenetic Insights into RASSF1A Regulated Pathways in Inflammatory Bowel Disease
DownloadFall 2018
Inflammatory Bowel Disease (IBD) is an idiopathic non-curable disease characterized by pain, chronic diarrhea, rectal bleeding with weight loss and erosion of the colon in severe cases. In many cases, IBD is a chronic relapsing inflammatory disorder of the gastrointestinal tract that usually...
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Fall 2017
The information contained in our genome is essential for the proper functioning of different physiological processes in cells that are required for our growth and survival, making the maintenance of genome integrity a task of utmost priority. Our cells have evolved a highly elaborate, complex and...
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Molecular Basis of Escherichia coli L/F transferase: Catalytic Mechanism and Substrate Specificities
DownloadFall 2014
The Escherichia coli leucyl/phenylalanyl-tRNA protein transferase (L/F transferase) catalyzes the tRNA-dependent post-translational addition of amino acids onto the N-terminus of a protein polypeptide substrate. The enzymatic N-terminal addition of an amino acid to a protein has been identified...
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Fall 2011
Topoisomerase II-beta binding protein 1 (TopBP1) is a critical regulatory protein that integrates diverse signals in the DNA damage response. In response to DNA replication stress, TopBP1 participates in a series of protein interactions to collectively activate the key Ser/Thr kinase, Ataxia...
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Spring 2013
K63-linked polyubiquitin is synthesized by the E2 Ubc13, and plays non-degradative roles in immunity and the DNA damage response, yet a full molecular understanding of its synthesis and subsequent recognition remains incomplete. Although previously considered a slow enzyme, we demonstrate that...