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Skip to Search Results- 2Sapkota, Shraddha
- 1Aglah, Conrad
- 1Ahmetovic, Alisa
- 1Alles, Sascha R
- 1Alpaugh, Melanie J
- 1Alston, Lauren L
- 13Spinal cord injury
- 7Rats. Nervous system.
- 7Stroke
- 6Human locomotion.
- 6Microglia
- 6Spinal cord. Wounds and injuries. Animal models.
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Alterations to the Membrane Properties of CA1 Pyramidal Neurons by the Amnestic Agent Anisomycin
DownloadSpring 2017
The notion that long-term memory is dependent upon the production of new proteins is a near-axiomatic assertion in the field of behavioural neuroscience. The idea that protein synthesis is required for long-term memory formation and maintenance is based largely on the amnestic effects of protein...
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Amino acid and biogenic amine concentrations during experimental autoimmune encephalomyelitis and the disease-modifying effects of phenelzine treatment
DownloadFall 2011
The project described in this thesis began with a broad analysis of the changes to amino acid and biogenic amine concentrations in the central nervous system (CNS) during experimental autoimmune encephalomyelitis (EAE) in mice, an animal model of Multiple Sclerosis (MS). That study identified...
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Spring 2016
There is ample evidence that autophagy is affected in Alzheimer’s disease (AD) but the causes, the nature of the dysfunction and the mechanisms of autophagy impairment are unclear. Autophagy depends on vesicular trafficking and membrane fusion, events that rely on several protein complexes and...
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Assessment of Small Sensory Fibers in Carpal Tunnel Syndrome Using Quantitative Sensory Testing
DownloadSpring 2012
Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy in humans. The gold standard for diagnosing CTS is considered to be nerve conduction studies (NCS). However, there are patients who complain of a lot of symptoms with minimal findings in NCS. One of the reasons for this...
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Spring 2014
People with a repressive stress coping style have high levels of unacknowledged anxiety. Repressors are thought to show attentional vigilance-avoidance patterns towards threat information, followed by memory reductions. The direct relationships between attention and memory for threat in...
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Augmenting Plasticity and Recovery from Stroke by Modulating the Extracellular Matrix of the Central Nervous System
DownloadFall 2017
Recovery following stroke occurs almost entirely in the first weeks post injury. Moreover, the efficacy of rehabilitative training is limited beyond this narrow time frame. Sprouting of spared corticospinal tract axons in the spinal cord makes a significant contribution to sensorimotor recovery,...
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Axon excitability testing shows increased IH activity in populations of slow versus fast motor axons of the rat
DownloadFall 2013
Despite extensive knowledge of variations in motoneuron (MN) soma and muscle properties across different healthy muscles or motor units, there is comparatively little knowledge about variations in motor axon electrophysiology across different axon groups. Axon excitability testing (AET) is an in...
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Broccoli sprout supplementation during placental insufficiency confers structural and functional neuroprotection to the fetal rat
DownloadSpring 2010
Background: Perinatal ischemic brain injury leads to developmental disability (DD), which accounts for 30% of disabilities in children. Antepartum risk, or risk occurring prior to birth occurs in more than 90% of cases. This study investigated whether maternal ingestion of a natural health...