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Skip to Search Results- 2Sapkota, Shraddha
- 1Aglah, Conrad
- 1Ahmetovic, Alisa
- 1Alles, Sascha R
- 1Alpaugh, Melanie J
- 1Alston, Lauren L
- 13Spinal cord injury
- 7Rats. Nervous system.
- 7Stroke
- 6Human locomotion.
- 6Microglia
- 6Spinal cord. Wounds and injuries. Animal models.
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The Role of Attention and Perception in the Control of Visually Guided and Memory-Guided Actions
DownloadFall 2012
I investigated the attentional and perceptional mechanisms involved in the control of visually guided and memory-guided actions in two experiments using event-related potentials (ERPS). In the first dual task experiment, participants performed reciprocal aiming in visually guided and...
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Spring 2017
MS is a chronic demyelinating disease of the CNS that presents with debilitating symptoms in the later stages of disease progression and therefore a high demand for targeted disease-modifying treatments exists. In order to create effective treatments the causalities between the symptoms and...
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The Role of Mitochondrial Dynamics on Neurodegenerative Processes of Multiple Sclerosis in Respose to Inflammation and Endoplasmic Reticulum Stress
DownloadFall 2014
Biopsies and post-mortem tissue of patients with multiple sclerosis (MS) as well as inflammatory demyelinating animal models show that endoplasmic reticulum (ER) stress is a hallmark of the progression of these pathologies. Moreover, MS biopsies and animal models of neuroinflammatory diseases...
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Fall 2010
Brainstem derived serotonin (5-HT) normally facilitates spinal motoneuron excitability and inhibits sensory afferent transmission and associated spinal reflexes. Because the 5-HT innervation of the spinal cord is almost exclusively derived from brainstem neurons, spinal cord injury leads to an...
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The Study of Hereditary Spastic Paraplegia Genes Using Drosophila Homologues: Behavioural Insights
DownloadFall 2014
Hereditary Spastic Paraplegia (HSP) denotes a heterogeneous group of heritable neurodegenerative disorders predominantly characterized by progressive weakness and spasticity of the legs. Mutations in the gene SPAST are by far the most common, while mutations in the gene ATL1 are the second most...
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Fall 2011
The locomotor Central Pattern Generator (CPG) is a neuronal network capable of producing rhythmic locomotor output independent of sensory or descending input. Attempts to identify component interneurons of the CPG have been aided by the discovery of transcription factors that are expressed by...
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Therapeutic effects of ganlgioside GM1 and gangliomimetic compounds in multiple models of Huntington disease
DownloadSpring 2016
Huntington disease (HD) is a neurodegenerative disorder that results in motor, cognitive and psychiatric deficits. The disease is caused by the expansion of a polyglutamine stretch in huntingtin (HTT), a ubiquitous protein with unclear functions. The molecular mechanisms underlying...