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Skip to Search Results- 2Sapkota, Shraddha
- 1Aglah, Conrad
- 1Ahmetovic, Alisa
- 1Alles, Sascha R
- 1Alpaugh, Melanie J
- 1Alston, Lauren L
- 13Spinal cord injury
- 7Rats. Nervous system.
- 7Stroke
- 6Human locomotion.
- 6Microglia
- 6Spinal cord. Wounds and injuries. Animal models.
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The effect of long-term interleukin-1 beta exposure on sensory neuron electrical membrane properties: implications for neuropathic pain
DownloadSpring 2011
The effect of interleukin-1 beta (IL-1β) on the electrical properties of sensory neurons was assessed at comparable levels and exposure times to those found in animal models of neuropathic pain. Experiments involved whole cell current- or voltage-clamp recordings from rat dorsal root ganglion...
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The effects of antidepressants on the phenotype of activated microglia and ischemia-injured cortical neurons
DownloadFall 2013
Depression is one of the most common disorders appearing following a stroke and is also a major factor limiting recovery and rehabilitation in stroke patients. Several antidepressants have shown to have anti-inflammatory properties within the central nervous system (CNS). The major source of...
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The Effects of Docosahexaenoic Acid (DHA) Dietary Supplementation in a Mouse Model of Stargardt-like Macular Dystrophy (STGD3)
DownloadFall 2013
Underlying mechanisms of how docosahexaenoic acid (DHA) might impact the progression of macular degeneration are unknown. We relied on the ELOVL4 mouse model of juvenile macular degeneration, STGD3, to test the hypothesis that antenatal DHA dietary supplementation (2% w/w of total fatty acid)...
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The effects of fructose feeding on the quantal catecholamine release from adrenal chromaffin cells
DownloadSpring 2014
The fructose-fed rat is an animal model of metabolic syndrome, which includes the development of hypertension. In other animal models of hypertension, an increase in the amount catecholamine released from chromaffin cells was reported. Employing carbon fibre amperometry, I tested the hypothesis...
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Spring 2013
Glucose is the sole fuel for the brain in normal physiological conditions. Absence of glucose or its presence in high concentrations has been shown to be harmful to neurons. Microglia, the innate immune cells of the brain, are the first line of defense against changes in the CNS environment and...
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Fall 2014
The visuomotor pathways of the brain are comprised of millions of neurons and complex interconnections among them exist. In order to fully understand visuomotor processes, we needto understand the mechanisms that allow neurons within these areas and between networks to coordinate with each other....
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The glutamate transporters' role in neuropathic pain and cognitive deficits in an animal model of multiple sclerosis
DownloadFall 2013
Multiple Sclerosis (MS) is a chronic disease of the central nervous system characterized by demyelination, inflammation and axonal injury. Chronic pain and cognitive deficits affect a large percentage of MS patients. While a number of animal models are available to study the pathophysiology of...
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The neural mechanisms of recognition memory: an investigation of study and test brain activity and their influence on memory outcomes
DownloadFall 2017
The ability to remember is fundamental to human cognition. The recognition memory paradigm has been widely used to investigate memory-related processes at both study and test phase. Two types of recognition memory are examined here, item and associative recognition memory. In an item recognition...
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The role fo the adrenergic system in the recovery of motoneuron excitability and spasms after spinal cord injury
DownloadSpring 2011
Brainstem derived noradrenaline (NA) in the spinal cord functions both to increase motoneuron excitability, by facilitating calcium-mediated persistent inward currents (Ca PICs), and to inhibit sensory afferent transmission to motoneurons (excitatory postsynaptic potentials; EPSPs). Spinal cord...