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Broccoli sprout supplementation during placental insufficiency confers structural and functional neuroprotection to the fetal rat
DownloadSpring 2010
Background: Perinatal ischemic brain injury leads to developmental disability (DD), which accounts for 30% of disabilities in children. Antepartum risk, or risk occurring prior to birth occurs in more than 90% of cases. This study investigated whether maternal ingestion of a natural health...
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Spring 2017
MS is a chronic demyelinating disease of the CNS that presents with debilitating symptoms in the later stages of disease progression and therefore a high demand for targeted disease-modifying treatments exists. In order to create effective treatments the causalities between the symptoms and...
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The Study of Hereditary Spastic Paraplegia Genes Using Drosophila Homologues: Behavioural Insights
DownloadFall 2014
Hereditary Spastic Paraplegia (HSP) denotes a heterogeneous group of heritable neurodegenerative disorders predominantly characterized by progressive weakness and spasticity of the legs. Mutations in the gene SPAST are by far the most common, while mutations in the gene ATL1 are the second most...
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Therapeutic effects of ganlgioside GM1 and gangliomimetic compounds in multiple models of Huntington disease
DownloadSpring 2016
Huntington disease (HD) is a neurodegenerative disorder that results in motor, cognitive and psychiatric deficits. The disease is caused by the expansion of a polyglutamine stretch in huntingtin (HTT), a ubiquitous protein with unclear functions. The molecular mechanisms underlying...