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Skip to Search Results- 1Amin, MD Ruhul
- 1Casey Carlisle
- 1DuVal, Michele G.
- 1Leighton, Patricia LA
- 1Mackowetzky, Kacey
- 1Nathan Joseph Nadolski
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Form and Function of Photoreceptors in kcnv2 Mutant Zebrafish: Implications for the Human Disease KCNV2 Retinopathy
DownloadFall 2020
KCNV2 retinopathy is a rare inherited retinal disease caused by mutations in the gene KCNV2, which encodes the potassium channel subunit KV8.2. Expressed by photoreceptors, KV8.2 is a critical component for the efficient generation of a neural response to light. KCNV2 retinopathy is characterized...
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Fall 2018
Vertebrate vision is mediated through the absorption of light by the rod and the cone photoreceptors. Early jawed vertebrates initially had four cone subtypes, which sampled different regions of the visual spectrum to allow colour vision, and a single rod type which enabled vision in dim light....
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Fall 2023
The intestinal epithelium is a complex tissue monolayer composed of regionally and functionally specialized cells. Given epithelial exposure to harsh and varied luminal conditions, epithelial cells continuously regenerate to sustain the barrier against environmental factors, including microbial...
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Spring 2022
Cannabis is one of the most commonly used illicit recreational drugs and is widely used for medicinal purposes. Cannabis contains three primary cannabinoids: 9-Tetrahydrocannabinol (THC), Cannabidiol (CBD) and Cannabinol (CBN). The psychoactive ingredient in cannabis is THC, whereas the major...
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Investigation of the Genetic Etiology of Superior Coloboma and the Formation and Closure of Superior Ocular Sulcus
DownloadSpring 2022
Congenital ocular coloboma is a rare genetic disorder that is typically observed as a cleft in the inferior aspect of the eye due to failed choroid fissure closure during embryogenesis. Together with microphthalmia (small eyes) and anophthalmia (absence of eyes), it represents 3-11% of childhood...
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Protein Quality Control Systems of the Thick Filament Protein Myosin in Zebrafish Skeletal Muscle Assembly and Maintenance
DownloadFall 2019
Skeletal and cardiac muscle function is dependent on the proper assembly and maintenance of the smallest contractile unit of striated muscle, the sarcomere. The sarcomere is composed of hundreds of proteins and associated factors, each of which must be properly folded, inserted into the...
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Regulatory factors gdf6a, tbx2b, and thr beta in generation of multiple cone photoreceptor subtypes; and intersections of genetic factors SOD1, TDP43, and gdf6a in zebrafish models of amyotrophic lateral sclerosis
DownloadFall 2018
The work within this thesis may be divided into two major foci with a unifying theme of understanding neurodegeneration and expanding the foundational knowledge necessary for treatment of two major degenerative diseases: macular degeneration and amyotrophic lateral sclerosis. To these ends the...
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Retinoic Acid Signaling in Late Vestibular Development of the Inner Ear and Techniques for Visualizing the Zebrafish Inner Ear
DownloadFall 2021
The vertebrate inner ear is a labyrinthine sensory organ responsible for perceiving sound and body motion. A wide range of disorders of the inner ear can arise from congenital disorders, necessitating the identification of molecular components or pathways involved in its development to better...
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Zebrafish Targeted Mutagenesis to Unveil Normal Physiological Functions of, and Interactions between, Prion Protein (PrP) and Amyloid Precursor Protein (APP): Relevance to Alzheimer’s disease
DownloadSpring 2017
Much of the work on Prion Protein (PrPC) and Amyloid Precursor Protein (APP) biology has focused on the contributions of their misfolded forms or aggregated metabolites to prion diseases and Alzheimer’s disease, respectively. As subversion/partial loss of some normal functions are also likely...