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New Insights into the Mechanisms of Vascular Dysfunction in a Young and Aged Septic Murine Model
DownloadFall 2022
Background: Sepsis is a dysregulated response to infection that results in life-threatening organ dysfunction. The elderly are disproportionately affected by sepsis and suffer an alarmingly high mortality rate. We hypothesized that increased mortality in the aged is due to a more highly...
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Vascular Adaptations to Pregnancy in a Rat Model of Advanced Maternal Age: Endoplasmic Reticulum Stress as a Potential Target for Therapeutic Intervention
DownloadSpring 2023
Advanced maternal age (≥35 years) increases the risk of pregnancy-specific complications such as reduced fetal growth and preeclampsia. The Davidge laboratory previously showed poor pregnancy outcomes and vascular dysfunction in a rat model of advanced maternal age. However, vascular adaptations,...