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Fall 2024

Pontillas, Shienna Marie A

Gene therapy offers a promising approach for treatment of a diverse array of diseases at their genetic root causes. The cationic polyethyleneimine (PEI) has been extensively used for successful non-viral nucleic acid delivery in experimental systems, but its clinical utility has been hampered by...

Fall 2019

Thapa, Bindu

Targeting a single pathway is not enough to treat cancer because of compensatory mechanisms against anticancer therapy via alternative molecular pathways for survival and proliferation of malignant cells. Given the unacceptable toxicity associated with conventional therapy, nucleic acids such as...

Spring 2022

Peng, Yi-Yang

Small interfering ribonucleic acids (siRNA) effectively downregulate the specific gene expression from cleaving the associated messenger RNA (mRNA) in the cytoplasm, which is a promising strategy in cancer management as one of the origins of cancer is the unregulated expression of the oncogene....

Fall 2021

Meenakshi Sundaram, Daniel Nisakar

RNA interference (RNAi) is a promising technology to specifically target the upregulated genes that provide uncontrolled proliferation and survival of cancers. The target specific silencing is accomplished by the delivery of small interfering RNA (siRNA), which require safe delivery systems to...

Spring 2017

Valencia Serna, Juliana

BCR-ABL fusion oncogene is the main driver mutation of Chronic Myeloid Leukemia (CML) that controls initiation, maintenance and progression to more aggressive stages of the disease. Current therapies with tyrosine kinase inhibitors in CML involve certain limitations, such as drug resistance and...