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Engineering Gene Vectors: Synthesis of Thioether-Lipid Polyethyleneimine Conjugates for pDNA and siRNA Delivery
DownloadFall 2024
Gene therapy offers a promising approach for treatment of a diverse array of diseases at their genetic root causes. The cationic polyethyleneimine (PEI) has been extensively used for successful non-viral nucleic acid delivery in experimental systems, but its clinical utility has been hampered by...
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Spring 2022
Small interfering ribonucleic acids (siRNA) effectively downregulate the specific gene expression from cleaving the associated messenger RNA (mRNA) in the cytoplasm, which is a promising strategy in cancer management as one of the origins of cancer is the unregulated expression of the oncogene....