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- 2mitochondria
- 2sexual dimorphism
- 2soluble epoxide hydrolase
- 1Cardioprotection
- 1Cytochrome P450
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Cardioprotective Effects of Soluble Epoxide Hydrolase Inhibition Following Myocardial Infarction
DownloadFall 2020
Ischemic heart disease (IHD) is a significant cause of morbidity and mortality for Canadians. While mortality rates from myocardial infarction (MI) and heart failure (HF) have decreased, IHD remains the number one cause of premature mortality. Both age and sex are important contributors for IHD...
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Cardioprotective effects of n-3 and n-6 PUFA derived epoxylipids against age-related cardiac alterations
DownloadSpring 2021
Age-associated changes leading to a decline in cardiac structure and function contribute to the increased susceptibility and incidence of cardiovascular diseases (CVD) in elderly individuals. A steady decline in mitochondrial function is recognized as an important biological consequence found in...
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Fall 2012
Ischemic heart disease remains a major cause of illness, disability and death worldwide, as such there remains a need for novel pharmacological agents that protect against myocardial ischemia reperfusion (I/R) injury. Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP) epoxygenase...