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The lysosomotropic agent siramesine induces cell death in prostate cancer cells and synergizes with the tyrosine kinase inhibitor lapatinib
DownloadFall 2024
Prostate cancer is the most diagnosed cancer affecting Canadian men. Prostate tumors that progress from localized disease to advanced stages show resistance to standard therapy, a major problem that requires alternative treatments. One new treatment possibility is targeting lysosomal membrane...
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The Role of the Androgen Receptor in Prostate Cancer-induced Platelet Aggregation and Invasion
DownloadFall 2019
Background: Prostate cancer (PCa) is the most common visceral malignancy and third leading cause of cancer death among men in Canada. The 2018 Canadian Cancer Society estimates suggest that 21,300 men were diagnosed and 4,100 patients died of this disease. Metastatic prostate cancer (mPCa) is...