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Mechanosensory and Sphingolipid Mediators of Inflammatory Signaling in Placental Dysfunction
DownloadFall 2022
Preeclampsia (PE) is a leading cause of maternal and fetal morbidity. Placental dysfunction plays a key role in PE and includes decreased syncytialization and increased inflammation and cell death. Tumor Necrosis Factor alpha (TNF-α) is a key factor in inducing this dysfunction. The controversy...
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Prenatal Hypoxia and the Impact of Maternal Antioxidant (MitoQ) Treatment on Developmental Programming of Cardiovascular Disease
DownloadFall 2018
Cardiovascular disease is the primary cause of morbidity and mortality worldwide. Prenatal hypoxia (due to placental or maternal hypoxia) is an established risk factor for cardiovascular disease. Hypoxia in pregnancy can lead to intrauterine growth restriction (IUGR; defined as a fetus who does...