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Investigation of the role of UBE4B ubiquitin ligase in p53 regulation in response to DNA damage in ATM-proficient and ATM-deficient cells
DownloadFall 2017
The tumour suppressor protein p53 maintains genomic integrity by coordinating the DNA damage response, which includes growth arrest, DNA damage repair, and apoptotic cell death. p53 is mutated in more than 50% of human cancer, which reflects its importance. The complex mechanism that controls the...
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Spring 2024
DNA double-strand breaks (DSBs) are considered the most deleterious DNA lesions. Unrepaired or incorrectly repaired DSBs can lead to cell cycle arrest, apoptosis, or over time, the accumulation of mutations and chromosomal abnormalities that give rise to cancer. The repair of DSBs by homologous...