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Fall 2019
Background: Global longitudinal strain (GLS) is currently a widely applied method to evaluate early left ventricular dysfunction in the oncology population. Its ability to predict left ventricular dysfunction is valid even in patients with normal ejection fraction. A significant limitation is...
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Colorectal Cancer Small Extracellular Vesicles Induce Matrix Metalloproteinase Expression, an Invasion-Promoting Phenotype, and CD147-Dependent MAPK/AP-1 Activation in Macrophages
DownloadFall 2020
Exosomes and small microvesicles are types of small extracellular vesicle (sEVs) secreted by cancerous and normal cells. sEVs are filled with cargo from cancer cells that may affect both nearby and distant tissues. sEVs from colorectal cancers that enter blood vessels draining the intestine will...
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Fall 2018
Colchicine is an anti-mitotic drug that targets unpolymerized tubulin, and inhibits microtubule polymerization. It is primarily used to treat gout but has been investigated in numerous clinical trials to treat conditions such as leukemia (ALL), prostate cancer, and inflammatory diseases. However,...
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Spring 2019
Introduction:Cancer-associated cachexia is defined as a multifactorial syndrome characterized by loss of body weight with specific losses of skeletal muscle and adipose tissue. Cachexia is driven by a variable combination of reduced food intake (FI) and distinct tumor-associated metabolic...