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Augmenting Hypothermia Therapy for Hypoxic-Ischemic Encephalopathy in Neonates: Localizing Drug Delivery using pH and Temperature Responsive Nanoparticles
DownloadFall 2022
The obstruction of blood flow to regions of an infant brain leads to a reduction of oxygen and essential nutrients, causing what is known as hypoxic-ischemic (HI) damage to that region. Presently the only treatment available for affected neonates is hypothermia: head or whole-body cooling....
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Spring 2024
Luminescent silicon quantum dots (SiQDs) are attractive nanoparticles due to the utilization of non-toxic and earth-abundant silicon. Despite these advantages, challenges in optimizing their optical properties, particularly broad luminescence bandwidths and photostability, persist. This thesis...
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Prenatal Hypoxia and the Impact of Maternal Antioxidant (MitoQ) Treatment on Developmental Programming of Cardiovascular Disease
DownloadFall 2018
Cardiovascular disease is the primary cause of morbidity and mortality worldwide. Prenatal hypoxia (due to placental or maternal hypoxia) is an established risk factor for cardiovascular disease. Hypoxia in pregnancy can lead to intrauterine growth restriction (IUGR; defined as a fetus who does...
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Fall 2024
Mesoporous silica nanoparticles (MSNPs) are used in catalysis, drug delivery, controlled drug release, imaging and biosensing applications due to their stability, high pore volumes, large surface area and non-toxicity. Although MSNPs have many advantages in biological applications, they lack...