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- 1Bahojb Habibyan, Yasaman
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Spring 2021
Ticks vector diverse pathogenic bacteria that are important to identify in public health. Recent advances in high throughput sequencing have allowed a comprehensive catalog of these bacteria to be compiled for individual ticks. In this thesis I identify the bacterial assemblages associated with...
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Fall 2024
Background: Periodontitis is a multifactorial, complex chronic oral disease facilitated by oral microbes. Transmissibility studies of the past have shown that oral microbes are transmissible between individuals. Furthermore, periodontal disease phenotypes also appear to be inheritable to some...
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Spring 2020
Animals live in close association with communities of microbes that play important roles modulating host nutrition, immunity, health, and behavior. Many of these microbes live on or in their animal host, most notably in the vertebrate gut, but microbiome studies now encompass disparate taxa from...
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Differential signature of the microbiome and neutrophils in the oral cavity of HIV-infected individuals
DownloadSpring 2022
HIV infection is associated with a wide range of changes in microbial communities and immune cell components of the oral cavity. The purpose of this study was to evaluate the oral microbiome in relationship to oral neutrophils in HIV-infected compared to healthy individuals. We evaluated oral...
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Ecological Dynamics of Microbiomes in Food Processing Facilities: Pathways to Improved Sanitation
DownloadFall 2024
Food processing environments serve as complex niches for bacterial colonization, adaption, persistence and dispersal, which subsequently shapes the microbial composition and diversity. This Ph.D. dissertation investigated the impact of biofilm formation, bacterial communication and cooperation on...
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Evaluation of fecal microbial transplant as a treatment method for disruption of the gut microbiota associated with short bowel syndrome in neonates.
DownloadFall 2021
Background Short bowel syndrome (SBS) is the leading cause of intestinal failure (IF), wherein either the function of the intestines is suboptimal, or length has been reduced due to congenital or acquired conditions, such that parenteral nutrition (PN) is required for >6 weeks. The most common...
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Fall 2021
Background A growing body of work has emerged which suggests that not only is the gut microbiome integral to maintaining human health, but also promising in the treatment of chronic inflammatory gastrointestinal diseases. Obesity and inflammatory bowel disease (IBD) are two such conditions with...
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Spring 2023
Intestinal epithelial damage and homeostatic cell shedding sends evolutionarily conserved growth signals to activate division programs in stem cells, which renews the epithelium to maintain barrier integrity. In addition to conserved growth and stress signaling, microbes and innate immune...
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Spring 2023
Mounting preclinical and clinical evidence strongly supports the crucial role of the gut microbiota in health. A dysbiosis of the microbiome, an imbalance of the microbial populations, may predispose newborns to develop various immune disorders later in life, such as Inflammatory Bowel Disease...