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Engineering Stable Bacteriophage Dosage Forms Active Against Antibiotic-Resistant Bacteria for Respiratory Delivery and Food Safety Applications
DownloadFall 2019
The topic of this thesis is the engineering of stable bacteriophage dosage forms that are active against antibiotic-resistant bacteria for applications in respiratory delivery and food safety. Experimental methods and theoretical models are developed to test and understand the effects that...
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Long-term effects of early-life gut microbiota perturbations on pancreatic islet development
DownloadFall 2021
Impaired secretion of insulin from pancreatic beta-cells, along with loss of cell mass, is one of the hallmarks of the pathogenesis of type 2 diabetes, a metabolic disorder characterized by chronic hyperglycemia. In humans, beta-cells’ ability to secrete insulin in response to glucose is acquired...