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Fall 2023
Proliferating cells, such as neonatal cardiomyocytes, have a high Warburg effect, which is a metabolic state in which there is high rates of glycolysis uncoupled from glucose oxidation under aerobic conditions. The Warburg effect is typically seen in cancerous cells and actively proliferating...
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Spring 2019
Dramatic maturational changes occur in heart energy metabolism in the fetal to newborn transition, most predominantly marked by a decrease in glycolysis and an increase in fatty acid oxidation which then becomes the major energy providing substrate for the heart after birth. However, in the...
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Membrane Type 1 Matrix Metalloproteinase Cleaves Low Density Lipoprotein Receptor to Regulate Lipid Metabolism
DownloadFall 2022
Low-density lipoprotein receptor (LDLR) mediates clearance of plasma LDL cholesterol (LDL-C) and protects against the development of atherosclerosis. Our previous studies demonstrated that membrane type-1 matrix metalloproteinase (MT1-MMP/MMP14) cleaves LDL receptor (LDLR) and exacerbates the...
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Spring 2012
The surgical repair of congenital heart defects (CHDs) often requires a bloodless/motionless field achieved by arresting the neonatal heart and exposing it to a period of ischemia. Metabolic manipulation, such as suppression of fatty acid (FA) oxidation, improves post-ischemic functional recovery...