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Spring 2023
Glycosylation is one of the most abundant and diverse post-translational modifications. Glycans participate in various key biological functions and processes including immunity, cell adhesion, endocytosis, exocytosis, molecular trafficking, and signal transduction. Previous work from our lab...
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Spring 2023
The discontinuous split-gene structure is a core feature of eukaryotic gene architecture and requires pre-mRNA splicing to remove silent intron sequences from the initial pre-mRNA transcript before it becomes a mature mRNA suitable for protein synthesis. Splicing begins with recognition of both...
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Fall 2024
The COVID-19 pandemic accelerated the development of mRNA vaccines, yet iden- tifying the optimal mRNA sequence for human use, particularly for the SARS-CoV- 2 spike protein, remains challenging. This thesis focuses on optimizing the open reading frame (ORF), a crucial mRNA component composed of...
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Spring 2021
The transcription factors FOXC1, FOXQ1, and FOXF2 (FOX cluster on chromosome 6) are members of the forkhead family that play a role in a plethora of biological processes during development and tumorigenesis. Emerging studies in the last decade have suggested a role of the FOX cluster in breast...