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Fall 2020
Background: Liver transplantation is the only definite cure for patients with end-stage liver diseases. Patients that receive a liver transplant are routinely followed with periodic Doppler ultrasound because it is safe, widely available and effective to diagnose and predict some complications....
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Fall 2023
Normothermic machine perfusion (NMP) is a novel method of organ preservation that has recently risen in prominence. NMP involves the maintenance of an organ outside the body to recreate its physiologic milieu, such as by providing oxygen and nutrients and maintaining temperature. We are only just...
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Membrane Type 1 Matrix Metalloproteinase Cleaves Low Density Lipoprotein Receptor to Regulate Lipid Metabolism
DownloadFall 2022
Low-density lipoprotein receptor (LDLR) mediates clearance of plasma LDL cholesterol (LDL-C) and protects against the development of atherosclerosis. Our previous studies demonstrated that membrane type-1 matrix metalloproteinase (MT1-MMP/MMP14) cleaves LDL receptor (LDLR) and exacerbates the...
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Role of Betaine Homocysteine Methyltransferase in Regulating Lipid Metabolism in McArdle RH7777 Cells
DownloadFall 2013
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. It is a clinical pathological state characterized by the accumulation of triacylglycerol (TG) in hepatocytes. It can progress to non-alcoholic steatohepatitis (NASH) and in some cases to fibrosis...