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Fall 2019
Persistent hyperexcitability in the primary sensory afferents contributes substantially to the onset and the maintenance of neuropathic pain. Inteleukin-1β (IL-1β) has been implicated to directly interact with interleukin 1 receptor type I (IL-1RI) expressed in dorsal root ganglion (DRG) neurons...
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Fall 2023
The immune system interacts reciprocally with the nervous system in order to accomplish facets of innate immunity via various mechanisms including toll-like receptors (TLRs). TLR activity leads to the release of cytokines which can effect acute and chronic pain states by promoting afferent neuron...