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Fall 2021
Ducks, as the natural reservoir host of influenza A virus (IAV), do not exhibit the same detrimental symptoms when infected by IAV as other susceptible host species, such as chickens and humans. A dysregulated NLRP3 inflammasome response activated by IAV has been linked to severe host outcomes,...
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CNS Inflammasome Activation and Pyroptosis in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
DownloadFall 2019
McKenzie, Brienne Alexandra Furfaro
Multiple sclerosis (MS) is a progressive and incurable demyelinating disease of the central nervous system (CNS). The neuropathogenesis of MS and its prototypic animal model, experimental autoimmune encephalomyelitis (EAE), is defined by persistent neuroinflammation, involving the activation of...