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Spring 2020
The knee menisci are a pair of weight-bearing fibrocartilaginous tissues between the femoral condyles and tibial plateau. They are essential for mechanical load distribution and transmission, lubrication, and stability of the knee joint. Meniscus injury is a risk factor for the onset of knee...
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Hemodynamic Differences in Recovery Following Chest Compression with Asynchronous Ventilation Using Chest Compression Rates of 90/min, 100/min, or 120/min in a Porcine Model of Neonatal Asphyxia
DownloadSpring 2020
Extensive neonatal resuscitation that involves chest compressions is an uncommon event impacting approximately 0.1% of term newborns, and up to 15% of preterm newborns. Despite best resuscitation efforts birth asphyxia results in approximately one million deaths annually worldwide. Neonatal...
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Fall 2021
BACKGROUND: Concurrent excitation of the sympathetic and parasympathetic systems occurs at high-altitude (chronic hypoxia), via the carotid chemoreflex. We have demonstrated this autonomic conflict manifests as cardiac arrhythmias during voluntary apnea. We sought to determine the duration of...
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Postnatal development of the purinergic signaling system in the preBötzinger Complex; implications for the hypoxic ventilatory response
DownloadFall 2023
Low oxygen (hypoxia) evokes the biphasic hypoxic ventilatory response (HVR), in which carotid-body chemoreceptors trigger a rapid increase in ventilation (VE) followed by a centrally-mediated, secondary hypoxic depression of respiration (HRD) and metabolic rate (VO2) that involves adenosine. In...
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Prenatal Hypoxia and the Impact of Maternal Antioxidant (MitoQ) Treatment on Developmental Programming of Cardiovascular Disease
DownloadFall 2018
Cardiovascular disease is the primary cause of morbidity and mortality worldwide. Prenatal hypoxia (due to placental or maternal hypoxia) is an established risk factor for cardiovascular disease. Hypoxia in pregnancy can lead to intrauterine growth restriction (IUGR; defined as a fetus who does...
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Fall 2022
BACKGROUND: Current evidence suggests that males and females regulate resting blood pressure differently. This may be a function of altered sympathetic activity, neurovascular coupling, or vascular smooth muscle receptor sensitivity. In this study, we wished to determine the role of...