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Postnatal development of the purinergic signaling system in the preBötzinger Complex; implications for the hypoxic ventilatory response
DownloadFall 2023
Low oxygen (hypoxia) evokes the biphasic hypoxic ventilatory response (HVR), in which carotid-body chemoreceptors trigger a rapid increase in ventilation (VE) followed by a centrally-mediated, secondary hypoxic depression of respiration (HRD) and metabolic rate (VO2) that involves adenosine. In...
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Prenatal Hypoxia and the Impact of Maternal Antioxidant (MitoQ) Treatment on Developmental Programming of Cardiovascular Disease
DownloadFall 2018
Cardiovascular disease is the primary cause of morbidity and mortality worldwide. Prenatal hypoxia (due to placental or maternal hypoxia) is an established risk factor for cardiovascular disease. Hypoxia in pregnancy can lead to intrauterine growth restriction (IUGR; defined as a fetus who does...