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Augmenting Hypothermia Therapy for Hypoxic-Ischemic Encephalopathy in Neonates: Localizing Drug Delivery using pH and Temperature Responsive Nanoparticles
DownloadFall 2022
The obstruction of blood flow to regions of an infant brain leads to a reduction of oxygen and essential nutrients, causing what is known as hypoxic-ischemic (HI) damage to that region. Presently the only treatment available for affected neonates is hypothermia: head or whole-body cooling....
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Spring 2021
Therapeutic hypothermia (TH) is a common intervention used in a variety of injury profiles. However, when applied to intracerebral hemorrhage (ICH), TH can worsen outcome. Previous research from our lab has shown that TH can aggravate intracranial bleeding both during cooling induction and...