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Cause of Death and the Impact of Implantable Cardioverter Defibrillators Among Patients with Diabetes Mellitus and Heart Failure
DownloadSpring 2020
Introduction: Diabetes and heart failure (HF) place a large burden on healthcare systems and are associated with increased risk for death, including sudden cardiac death (SCD). However, causes of death have not been fully explored and evidence for primary prevention...
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Fabry Cardiomyopathy and Heart Failure: The Roles of Inflammation and Valvular Heart Disease
DownloadSpring 2021
Fabry disease (FD) is an X-linked recessive multisystem disorder and an underrecognized secondary cause of hypertrophic cardiomyopathy. A gene variant encoding the enzyme α-galactosidase A results in deficient or absent hydrolase activity, resulting in the accumulation of glycosphingolipids in...
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Use of Guideline-directed Medical Therapy in Patients ≥65 years after the Diagnosis of Heart Failure: A Canadian Population-based Study
DownloadFall 2023
Background: Guideline-directed medical therapy (GDMT) improves clinical outcomes in patients with heart failure (HF) with reduced ejection fraction (HFrEF). Despite proven efficacy, GDMT are under-utilized in clinical practice. The current study examines GDMT utilization after incident...